Broad-spectrum antibiotics alter the microbiome, increase intestinal fxr, and decrease hepatic steatosis in zebrafish short bowel syndrome

Author:

Maselli Kathryn M.1,Gee Kristin1,Isani Mubina1,Fode Alexa1,Schall Kathy A.1,Grikscheit Tracy C.123ORCID

Affiliation:

1. Developmental Biology and Regenerative Medicine, Saban Research Institute, Children’s Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California

2. Department of Surgery, Division of Pediatric Surgery, Children’s Hospital Los Angeles, Los Angeles, California

3. Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California

Abstract

In a zebrafish model that replicates a common clinical scenario, systemic effects of the administration of broad-spectrum antibiotics in a zebrafish model of SBS identified two alternate states that led to the establishment of fat accumulation in the liver or its absence. Broad-spectrum antibiotics given to zebrafish with SBS over 2 wk altered the intestinal microbiome, decreased intestinal and hepatic inflammation, and decreased hepatic steatosis.

Funder

The Billy and Audrey Wilder Foundation

The Saban Research Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Gastroenterology,Hepatology,Physiology

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