Affiliation:
1. Gastrointestinal Research Laboratory, Department of Medicine, St. Luke's Hospital, New York City
Abstract
Studies of taurocholate and cholate-C14 absorption by slices of rat intestine reveal that an active absorptive mechanism obeying Michaelis-Menten kinetics is present in the ileum but absent in other portions of the gut. Following 1 day of bile duct cannulation, the in vitro absorption of bile salts was enhanced two- to three-fold. The normal tissue concentration of bile salts in the ileum reached 1.3 µm and in the jejunum 0.35 µm/g tissue water. The presence of endogenous bile salts resulted in inhibition of subsequent ileal active absorption competitively suggesting the existence of a common receptor site for mucosal bile salt absorption. Active absorption was dependent on sodium concentration and inhibited by potassium. The significance of these results is discussed.
Publisher
American Physiological Society
Cited by
86 articles.
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