Renal Conservation of Trimethylamine Oxide by the Spiny Dogfish, Squalus Acanthias-Reference-Cited by-同舟云学术

Renal Conservation of Trimethylamine Oxide by the Spiny Dogfish, Squalus Acanthias

Published:1958-08-01 Issue:2 Volume:194 Page:229-235
ISSN:0002-9513
Container-title:American Journal of Physiology-Legacy Content
language:en
Short-container-title:American Journal of Physiology-Legacy Content

Author:

Cohen Julius J.¹,Krupp Marcus A.¹,Chidsey Charles A.¹

Affiliation:

1. From the Department of Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio and the Mount Desert Island Biological Laboratory, Salisbury Cove, Maine

Abstract

Trimethylamine oxide (Oxide) plasma concentrations in the dogfish have been found to be maintained within the narrow range of 60–80 µmol/ml. These levels are maintained in spite of prolonged (up to 41 days) fasting. The Oxide is freely filterable at the glomerulus but is avidly reabsorbed by the renal tubule. Thus, less than 10% of the filtered Oxide appears in the urine. Dogfish urine has been found to contain an unidentified volatile amine, not NH3, presumed to be trimethylamine. The possible role of the Oxide in elasmobranch physiology is discussed.

Publisher

American Physiological Society

Subject

Physiology (medical)

Link

https://www.physiology.org/doi/pdf/10.1152/ajplegacy.1958.194.2.229

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