Interactions between the eye and hand motor systems: disruptions due to cerebellar dysfunction

Abstract

1. We tested the hypothesis that interactions occur between eye and hand movements produced in conjunction. This was accomplished by having human subjects with cerebellar dysfunction and age-matched controls perform two tasks: 1) tracking a moving target with the hand and 2) performing a pointing movement to intercept the target. Our prediction was that the inaccuracies that are characteristic of eye and hand movements generated in isolation by cerebellar subjects would be accentuated in each system during combined eye-hand tasks. 2. The cerebellar subjects took longer to respond to the onset of target motion in both tasks. This was true for both the eyes and hand, regardless of whether the eye and hand movements were generated in isolation or in conjunction with each other. 3. The cerebellar subjects also displayed a larger degree of error and/or variability in their hand movements than the control subjects. A significant amount of this increased variability was due to systematic changes in the trajectory of the hand during the critical periods leading up to and after each ocular saccade. These systematic changes were consistent with an overestimation of target velocity in the perifoveal visual field. 4. The increased variability of the cerebellar subjects' hand movements was markedly reduced by restricting eye movements. A similar reduction in variability occurred when vision of the hand was restricted in the tracking task. This effect was accompanied by improved eye movements. 5. For both sets of subjects the eye movements were affected by the hand movements produced in the tracking task. In particular, eye movement accuracy was improved in the controls and degraded in the cerebellar subjects when compared with the eye movements generated in isolation. In contrast, no changes were observed in the interception task. 6. Taken together, these results imply that a reciprocal interaction occurs between the eye and hand motor systems and/or that common “upstream” sites influence each of these systems in a similar manner. The functional anatomy and neurophysiological characteristics of several sites where such interactions may take place are discussed.