Short-term high-calorie high-fat feeding induces hyperinsulinemia and blunts skeletal muscle microvascular blood flow in healthy humans-Reference-Cited by-同舟云学术

Short-term high-calorie high-fat feeding induces hyperinsulinemia and blunts skeletal muscle microvascular blood flow in healthy humans

Published:2024-07-01 Issue:1 Volume:327 Page:E42-E54
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Brayner Barbara¹,Keske Michelle A.¹^ORCID,Roberts-Thomson Katherine M.²,Parker Lewan¹^ORCID,Betik Andrew C.¹^ORCID,Thomas Hannah J.³,Mason Shaun¹,Way Kimberley L.¹⁴⁵^ORCID,Livingstone Katherine M.¹,Hamilton D. Lee¹,Kaur Gunveen¹^ORCID

Affiliation:

1. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia

2. Australian Catholic University, Melbourne, Victoria, Australia

3. Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia

4. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

5. Exercise Physiology and Cardiovascular Health Lab, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

Abstract

This is the first study to investigate skeletal muscle microvascular blood flow (MBF) responses in humans after short-term high-calorie high-fat (HCHF) diet. The main findings were that HCHF diet causes elevated postprandial insulin in healthy individuals within 3 days and blunts meal-induced muscle MBF within 7 days, despite no impairments in postprandial glucose or macrovascular blood flow.

Funder

National Health and Medical Research Council & National Heart Foundation Early Career

National Health and Medical Research Council Emerging Leadership Fellowship

Alfred Deakin Post Doctoral Fellowship

Diabetes Australia

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00070.2024

Reference53 articles.

1. Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects

2. Short-Term Low-Carbohydrate High-Fat Diet in Healthy Young Males Renders the Endothelium Susceptible to Hyperglycemia-Induced Damage, An Exploratory Analysis

3. Short-term, high-fat overfeeding impairs glycaemic control but does not alter gut hormone responses to a mixed meal tolerance test in healthy, normal-weight individuals – ERRATUM

4. High-Fat Overfeeding Impairs Peripheral Glucose Metabolism and Muscle Microvascular eNOS Ser1177 Phosphorylation

5. Overfeeding Rapidly Induces Leptin and Insulin Resistance