Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases-Reference-Cited by-同舟云学术

Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases

Published:2023-06-01 Issue:6 Volume:324 Page:E542-E552
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Abuduwaili Halimulati¹,Kamoshita Kyoko¹,Ishii Kiyo-aki¹²³^ORCID,Takahashi Kenta⁴,Abuduyimiti Tuerdiguli¹,Qifang Li¹,Isobe Yuki¹,Goto Hisanori¹,Nakano Yujiro¹,Takeshita Yumie¹,Takayama Hiroaki¹⁵,Harada Kenichi⁴,Takamura Toshinari¹^ORCID

Affiliation:

1. Department of Endocrinology and Metabolism, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan

2. Department of Integrative Medicine for Longevity, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan

3. Department of Musculoskeletal Disease, National Center for Geriatrics and Gerontology (NCGG), Aichi, Japan

4. Department of Human Pathology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan

5. Department of System Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan

Abstract

Selenoprotein P (SeP) is a hepatokine that is upregulated in type 2 diabetes and aging and causes signal resistances via reductive stress. Immobilization (IMM) significantly reduced skeletal muscle mass in mice, which was prevented in SeP knockout (KO) mice. IMM-induced Foxos/KLF15-atrogene upregulation was suppressed in the skeletal muscle of KO mice. These findings suggest that SeP-mediated reductive stress is involved in and may be a therapeutic target for physical inactivity-mediated muscle atrophy.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Takeda Science Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00270.2022

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