Central GLP-1 contributes to improved cognitive function and brain glucose uptake after duodenum-jejunum bypass on obese and diabetic rats-Reference-Cited by-同舟云学术

Central GLP-1 contributes to improved cognitive function and brain glucose uptake after duodenum-jejunum bypass on obese and diabetic rats

Published:2021-09-01 Issue:3 Volume:321 Page:E392-E409
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Ruze Rexiati¹^ORCID,Xu Qian²,Liu Guoqin³,Li Yuekai⁴,Chen Weijie¹,Cheng Zhiqiang⁵,Xiong Yacheng²,Liu Shaozhuang⁶,Zhang Guangyong⁷,Hu Sanyuan⁷^ORCID,Yan Zhibo⁵⁸^ORCID

Affiliation:

1. Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China

2. Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, People’s Republic of China

3. Department of General Surgery, Jinan Central Hospital, Shandong University, Jinan, People’s Republic of China

4. Department of Nuclear Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China

5. Department of Colorectal Surgery, General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China

6. Department of Bariatric and Metabolic Surgery, General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China

7. Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, People’s Republic of China

8. Key Laboratory Experimental Teratology of the Ministry of Education and Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China

Abstract

The improvement of cognitive function following bariatric surgery has been highlighted while its mechanisms remain elusive. The brain glucose uptake of patients was improved after RYGB, and the DJB and sham surgery performed on obese and diabetic Wistar rats revealed that the elevated central GLP-1 contributes to the dramatic improvement of cognitive function, brain glucose uptake, transport, glucose sensing, and neuronal activation.

Funder

Fellowship of China Postdoctoral Science Foundation

NSFC | National Science Fund for Distinguished Young Scholars

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00126.2021

Reference82 articles.

1. Solving Population-wide Obesity — Progress and Future Prospects

2. The integrative biology of type 2 diabetes