Fasting potentiates insulin-mediated glucose uptake in rested and prior-contracted rat skeletal muscle-Reference-Cited by-同舟云学术

Fasting potentiates insulin-mediated glucose uptake in rested and prior-contracted rat skeletal muscle

Published:2022-05-01 Issue:5 Volume:322 Page:E425-E435
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Kido Kohei¹²³^ORCID,Egawa Tatsuro¹^ORCID,Watanabe Shinya²,Kawanaka Kentaro²³,Treebak Jonas T.⁴^ORCID,Hayashi Tatsuya¹

Affiliation:

1. Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan

2. Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan

3. Institute for Physical Activity, Fukuoka University, Fukuoka, Japan

4. Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark

Abstract

In this study, we revealed that 36 h of fasting additively upregulated acute muscle contraction-induced AMPK pathway activation in rats. Besides, fasting and muscle contraction synergistically enhanced insulin-stimulated site-specific TBC1D4 phosphorylation and glucose uptake, which was associated with augmented AMPK pathway activation. These results contribute to understanding the regulation of muscle insulin sensitivity.

Funder

MEXT | Japan Society for the Promotion of Science

Novo Nordisk Foundation Center for Basic Metabolic Research

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00412.2021

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