Human skeletal muscle methylome after low-carbohydrate energy-balanced exercise-Reference-Cited by-同舟云学术

Human skeletal muscle methylome after low-carbohydrate energy-balanced exercise

Published:2023-05-01 Issue:5 Volume:324 Page:E437-E448
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Gorski Piotr P.¹,Turner Daniel C.¹,Iraki Juma²^ORCID,Morton James P.³^ORCID,Sharples Adam P.¹^ORCID,Areta José L.³^ORCID

Affiliation:

1. Institute for Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway

2. Iraki Nutrition, Lørenskog, Norway

3. Research Institute for Sport and Exercise Sciences, John Moores University, Liverpool, United Kingdom

Abstract

We identify novel epigenetically regulated genes associated with train-low sleep-low paradigms. Exercise under low-carbohydrate (CHO) energy-balance (high-fat) conditions elicited a more prominent DNA hypomethylation signature 30 minutes postexercise compared with low-CHO energy-deficit (low-fat) conditions. This was enriched within IL6-JAK-STAT signaling, metabolic processes, p53, cell cycle, oxidative phosphorylation, and fatty acid metabolism. Histone deacetylase (HDAC) family members 2, 4, 10, and 11 demonstrated hypomethylation, with HDAC2 and HDAC11 possessing alternative regulation of gene expression in energy balance versus deficit conditions.

Funder

Norwegian School of Sport Sciences

Society of Endocrinology

Liverpool John Moores University

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00029.2023

Reference49 articles.

1. Fuel for the Work Required: A Theoretical Framework for Carbohydrate Periodization and the Glycogen Threshold Hypothesis