Effect of ghrelin on glucose tolerance, gut hormones, appetite, and food intake after sleeve gastrectomy-Reference-Cited by-同舟云学术

Effect of ghrelin on glucose tolerance, gut hormones, appetite, and food intake after sleeve gastrectomy

Published:2024-09-01 Issue:3 Volume:327 Page:E396-E410
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Hedbäck Nora¹²^ORCID,Dichman Marie-Louise¹³²,Hindsø Morten¹,Dirksen Carsten¹²⁴^ORCID,Jørgensen Nils Brun¹,Bojsen-Møller Kirstine Nyvold¹⁴^ORCID,Kristiansen Viggo B.³,Rehfeld Jens F.⁵,Hartmann Bolette²⁶^ORCID,Holst Jens Juul²⁶,Svane Maria Saur¹³^ORCID,Madsbad Sten¹^ORCID

Affiliation:

1. Department of Endocrinology, Copenhagen University Hospital, Hvidovre, Denmark

2. Department of Biomedical Sciences, SUND, University of Copenhagen, Copenhagen, Denmark

3. Department of Surgical Gastroenterology, Copenhagen University Hospital, Hvidovre, Denmark

4. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

5. Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Copenhagen, Denmark

6. Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark

Abstract

Ghrelin’s effect on glucose tolerance and food intake following sleeve gastrectomy (SG) was evaluated. Acyl-ghrelin was infused during a mixed-meal and ad libitum meals before and 3 mo after surgery. Postprandial glucose concentrations increased during ghrelin infusions, both before and after surgery, while insulin production was inhibited. However, ad libitum meal intake did not differ during ghrelin administration compared with placebo. The decreased ghrelin concentration following SG may contribute to the glycemic control after surgery.

Funder

EC | European Research Council

Hvidovre Hospital

Novo Nordisk Fonden

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00177.2024

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