Affiliation:
1. Department of Pediatrics, University of California San Diego, La Jolla, California, United States
Abstract
Our study reveals a progressive decline in maternal blood glucagon-like peptide 1 (GLP-1) concentration. GLP-1 receptor agonist injection in late pregnancy significantly reduced fetal body weight, even after restoration of maternal blood glucose concentration. GLP-1 receptor activation significantly reduced the placental labyrinth area, expression of some nutrient transporters, and capillary development. Our study indicates that reducing maternal blood GLP-1 levels is a physiological adaptation process that benefits placental development and fetal growth.
Funder
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development
HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases
Publisher
American Physiological Society