Mononuclear phagocyte morphological response to chemoattractants is dependent on geranylgeranyl pyrophosphate-Reference-Cited by-同舟云学术

Mononuclear phagocyte morphological response to chemoattractants is dependent on geranylgeranyl pyrophosphate

Published:2024-07-01 Issue:1 Volume:327 Page:E55-E68
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Krauklis Steven A.¹²^ORCID,Hussain Jamal³²,Murphy Katherine M.²,Dray Evan L.²,Ousley Carey G.²,Justyna Katarzyna⁴,Distefano Mark D.⁴,Steelman Andrew J.¹²⁵⁶,McKim Daniel B.¹²⁵⁶^ORCID

Affiliation:

1. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States

2. Department of Animal Sciences,University of Illinois at Urbana-Champaign, Urbana, Illinois, United States

3. Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States

4. Department of Chemistry, University of Minnesota, Minneapolis, Minnesota, United States

5. Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States

6. Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States

Abstract

The immunomodulatory effect of prenylation is ill-defined. We investigated the role of prenylation on the chemoattractant response to C5a. Simvastatin treatment inhibits the cytoskeletal remodeling associated with a chemotactic response. We showed that the chemoattractant response to C5a was dependent on geranylgeranylation, and proteomic analysis identified several geranylgeranylated proteins that are involved in C5a receptor signaling and cytoskeletal remodeling. Furthermore, they establish the role of geranylgeranylation in mediating the response to chemoattractant C5a.

Funder

HHS | National Institutes of Health

USDA | National Institute of Food and Agriculture

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00359.2023

Reference56 articles.

1. Effect of statins on the mortality of bacteremic patients: A systematic review and meta-analysis of clinical trials

2. Systematic Review and Meta-Analysis on the Association between Outpatient Statins Use and Infectious Disease-Related Mortality

3. Statin Therapy and Mortality from Sepsis: A Meta-analysis of Randomized Trials

4. Prophylactic simvastatin increased survival during endotoxemia and inhibited granulocyte trafficking in a cell-intrinsic manner

5. Concepts of GPCR ‐controlled navigation in the immune system