Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity-Reference-Cited by-同舟云学术

Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity

Published:2023-02-01 Issue:2 Volume:324 Page:E115-E119
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Castela Inês¹²³^ORCID,Morais Juliana³⁴,Barreiros-Mota Inês¹²,Silvestre Marta P.¹³,Marques Cláudia¹³,Rodrigues Catarina¹²,Ismael Shámila¹²³,Araújo João R.¹³,Ângelo-Dias Miguel¹²,Martins Catarina¹²,Borrego Luís Miguel¹²⁵,Monteiro Rosário³⁶⁷,Coutinho Sílvia Ribeiro⁸⁹,Calhau Conceição¹³,Martins Cátia⁸¹⁰¹¹,Faria Ana¹²³,Pestana Diogo¹³,Teixeira Diana¹²³

Affiliation:

1. NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, Lisbon, Portugal

2. CHRC, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, Lisbon, Portugal

3. CINTESIS@RISE, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, Lisbon, Portugal

4. UniC@RISE–Cardiovascular Research Centre, Faculdade de Medicina, Universidade do Porto, Porto, Portugal

5. Immunoallergy Department, Hospital da Luz–Lisboa, Lisbon, Portugal

6. Health Centre Grouping Porto Ocidental, Family Health Unit Homem do Leme, Porto, Portugal

7. Department of Community Medicine, Health Information and Decision, Faculdade de Medicina, Universidade do Porto, Porto, Portugal

8. Obesity Research Group, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway

9. Department of Public Health Nutrition at the Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway

10. Centre for Obesity, Department of Surgery, St. Olavs University Hospital, Trondheim, Norway

11. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama

Abstract

Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context of obesity. This study provides evidence to support adipose tissue dysfunction as a central feature of the pathophysiology of obesity and insulin resistance. Early identification of individuals at higher risk of developing metabolic complications through adipose tissue dysfunction assessment and the staging of obesity and its transient phenotypes can contribute to improve therapeutic decision-making.

Funder

Fundação para a Ciência e a Tecnologia

Comprehensive Health Research Center

CINTESIS - Centro de Investigação em Tecnologias e Serviços de Saúde

European Regional Development Fund

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00273.2022

Reference23 articles.