Characterization of one anastomosis gastric bypass and impact of biliary and common limbs on bile acid and postprandial glucose metabolism in a minipig model

Author:

Marciniak Camille1,Chávez-Talavera Oscar2,Caiazzo Robert1,Hubert Thomas1,Zubiaga Lorea1,Baud Gregory1,Quenon Audrey1,Descat Amandine3,Vallez Emmanuelle2,Goossens Jean François3,Kouach Mostafa3,Vangelder Vincent1,Gobert Mathilde1,Daoudi Mehdi1,Derudas Bruno2,Pigny Pascal3,Klein André4,Gmyr Valéry1,Raverdy Violeta1,Lestavel Sophie2ORCID,Laferrère Blandine5,Staels Bart2,Tailleux Anne2,Pattou François1ORCID

Affiliation:

1. U1190, Institut Pasteur de Lille, University of Lille, Inserm, Lille, France

2. U1011, Institut Pasteur de Lille, University of Lille, Inserm Lille, France

3. Mass Spectrometry Department, Pharmacy Faculty, PSM-GRITA, Lille, France

4. Metabolism and Glycosylation Diseases, Biology Pathology Center, Lille, France

5. Division of Endocrinology, Department of Medicine, New York Obesity Research Center, Columbia University Irving Medical Center, New York, New York

Abstract

Common limb mediates postprandial glucose metabolism change after gastric bypass whereas biliary limb contributes to weight loss.

Funder

Fondation Francophone de Recherche sur le Diabète

Agence Nationale de la Recherche

EC | European Research Council

Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

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