BDNF polymorphism and interhemispheric balance of motor cortex excitability: a preliminary study

Author:

Dubbioso Raffaele1ORCID,Pellegrino Giovanni2,Ranieri Federico3ORCID,Di Pino Giovanni4ORCID,Capone Fioravante5,Dileone Michele6,Iodice Rosa1,Ruggiero Lucia1,Tozza Stefano1ORCID,Uncini Antonino7,Manganelli Fiore1,Di Lazzaro Vincenzo5

Affiliation:

1. Department of Neurosciences, Reproductive Sciences, and Odontostomatology, University of Naples “Federico II,” Naples, Italy

2. Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

3. Neurology Unit, Department of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy

4. Research Unit of Neurophysiology and Neuroengineering of Human-Technology Interaction (NeXTlab), Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy

5. Unit of Neurology, Neurophysiology, and Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy

6. Faculty of Health Sciences, University of Castilla La Mancha, Talavera de la Reina, Spain

7. Department of Neuroscience, Imaging, and Clinical Sciences, University “G. d’Annunzio,” Chieti-Pescara, Italy

Abstract

BDNF Val66Met polymorphism might influence interhemispheric balance of motor cortex excitability. Specifically, Val/Val carriers display higher excitability of the left compared with the right primary motor cortex, whereas Met carriers do not show any significant corticomotor excitability imbalance. These preliminary results are relevant to understanding aberrant interhemispheric excitability and excitation/inhibition balance in neurological disorders.

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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