1. Department of Anesthesiology and Operative Intensive Care Medicine, Campus Charité Mitte and Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany
2. Institute of Physiology, Charité-Universitätsmedizin Berlin, Berlin, Germany
3. Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada
4. Departments of Physiology and Surgery, University of Toronto, Toronto, Ontario, Canada