P2X<sub>7</sub> signaling influences the production of pro-resolving and pro-inflammatory lipid mediators in alveolar macrophages derived from individuals with asthma-Reference-Cited by-同舟云学术

P2X₇ signaling influences the production of pro-resolving and pro-inflammatory lipid mediators in alveolar macrophages derived from individuals with asthma

Published:2023-10-01 Issue:4 Volume:325 Page:L399-L410
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Townsend Elizabeth A.¹^ORCID,Guadarrama Arturo²,Shi Lei²,Roti Roti Elon²^ORCID,Denlinger Loren C.²

Affiliation:

1. Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States

2. Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States

Abstract

Alveolar macrophages obtained from individuals with asthma produce soluble lipid mediators in response to P2X7 purinergic receptor signaling. Proinflammatory mediators may contribute to asthma exacerbations but proresolving mediators may help with resolution of asthma loss of control. These specialized proresolving lipid mediators may serve as future potential therapeutics for asthma exacerbation resolution and recovery.

Funder

William W. and Judith H. Busse Endowed Professorship in Allergy and Asthma Research

Foundation for Anesthesia Education and Research

HHS | NIH | National Heart, Lung, and Blood Institute

University of Wisconsin-Madison

Publisher

American Physiological Society

Subject

Cell Biology,Physiology (medical),Pulmonary and Respiratory Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00070.2023

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