FGF2 is secreted in extracellular vesicles from lung cells-Reference-Cited by-同舟云学术

FGF2 is secreted in extracellular vesicles from lung cells

Published:2024-09-01 Issue:3 Volume:327 Page:L359-L370
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Olave Nelida C.¹,Halloran Brian¹,Ambalavanan Namasivayam¹^ORCID

Affiliation:

1. Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States

Abstract

We found that multiple lung cell types release basic fibroblast growth factor (FGF2)-18kDa both directly into the extracellular environment (secretome), as well as in extracellular vesicles (EVs). Bronchial epithelial cells released more FGF2-18kDa in EVs during hyperoxia, which could be internalized rapidly by recipient cells. We also identified potential binding partners of FGF2-18kDa in nuclei that may mediate downstream effects that do not involve FGF2 binding to cell surface receptors. We also confirmed a potential angiogenic role for FGF2-18kDa.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00225.2023

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