Obesity impairs ciliary function and mucociliary clearance in the murine airway epithelium-Reference-Cited by-同舟云学术

Obesity impairs ciliary function and mucociliary clearance in the murine airway epithelium

Published:2024-09-01 Issue:3 Volume:327 Page:L406-L414
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Tanaka Yuko¹^ORCID,Fujisawa Tomoyuki¹^ORCID,Yazawa Shusuke¹^ORCID,Ohta Isao²,Takaku Yasuharu³,Ito Masahiko⁴,Inoue Yusuke¹^ORCID,Yasui Hideki¹^ORCID,Hozumi Hironao¹^ORCID,Karayama Masato¹^ORCID,Suzuki Yuzo¹^ORCID,Furuhashi Kazuki¹,Enomoto Noriyuki¹,Setou Mitsutoshi⁵,Inui Naoki⁶^ORCID,Suzuki Tetsuro⁴,Suda Takafumi¹

Affiliation:

1. Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan

2. Advanced Research Facilities and Services, Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of Medicine, Shizuoka, Japan

3. Laboratory of Bio-Design, Department of Agricultural Innovation for Sustainable Society, Tokyo University of Agriculture, Atsugi, Japan

4. Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Shizuoka, Japan

5. Department of Cellular and Molecular Anatomy and International Mass Imaging Center, Hamamatsu University School of Medicine, Shizuoka, Japan

6. Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Shizuoka, Japan

Abstract

Our study shows that obesity impairs airway mucociliary clearance (MCC), an essential physical innate defense mechanism for viral infection. Mechanically, this is likely due to the obesity-induced downregulation of cilia-related genes and attenuation of extracellular ATP release. This study provides novel insights into the mechanisms driving the higher susceptibility and severity of viral respiratory infections in individuals with obesity.

Funder

Daiwa Securities Health Foundation

MEXT | Japan Society for the Promotion of Science

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00114.2024

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