Histamine/H1 receptor signaling in the parafacial region increases activity of chemosensitive neurons and respiratory activity in rats

Author:

Sobrinho C. R.12ORCID,Milla B. M.2ORCID,Soto-Perez J.2ORCID,Moreira T. S.1,Mulkey D. K.2ORCID

Affiliation:

1. Department of Physiology and Biophysics, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil

2. Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut

Abstract

Histamine/H1 receptor signaling activates retrotrapezoid (RTN) neurons under control conditions and to a lesser extent in the presence of serotonin. These results suggest that RTN neurons have a limited capacity to respond to simultaneous activation of multiple Gq-coupled receptors.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

HHS | NIH | National Institute of Neurological Disorders and Stroke

HHS | NIH | National Heart, Lung, and Blood Institute

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

American Physiological Society

Subject

Physiology,General Neuroscience

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