Benzamil-mediated urine alkalization is caused by the inhibition of H+-K+-ATPases-Reference-Cited by-同舟云学术

Benzamil-mediated urine alkalization is caused by the inhibition of H+-K+-ATPases

Published:2021-04-01 Issue:4 Volume:320 Page:F596-F607
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Ayasse Niklas¹,Berg Peder¹,Andersen Jesper Frank¹,Svendsen Samuel Levi¹,Sørensen Mads V.¹,Fedosova Natalya U.¹^ORCID,Lynch I. Jeanette²³,Wingo Charles S.²³,Leipziger Jens¹⁴^ORCID

Affiliation:

1. Department of Biomedicine, Physiology, Aarhus University, Aarhus, Denmark

2. Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, Florida

3. North Florida/South Georgia Veterans Health System, Gainesville, Florida

4. Aarhus Institute of Advanced Studies, Aarhus University, Aarhus, Denmark

Abstract

Bolus application of epithelial Na+ channel (EnaC) blockers causes marked and acute increases of urine pH. Here, we provide evidence that the underlying mechanism involves direct inhibition of the H+-K+ pump in the collecting duct. This could provide a fundamental revision of the previously assumed mechanism that suggested a key role of ENaC inhibition in this response.

Funder

Independent Research Fund Denmark

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00444.2020

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