Sex differences in dietary sodium evoked NCC regulation and blood pressure in male and female Sprague-Dawley, Dahl salt-resistant, and Dahl salt-sensitive rats-Reference-Cited by-同舟云学术

Sex differences in dietary sodium evoked NCC regulation and blood pressure in male and female Sprague-Dawley, Dahl salt-resistant, and Dahl salt-sensitive rats

Published:2024-08-01 Issue:2 Volume:327 Page:F277-F289
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Kim Kiyoung¹,Nist Kayla M.²^ORCID,Puleo Franco¹,McKenna James³,Wainford Richard D.¹³^ORCID

Affiliation:

1. Department of Pharmacology and Experimental Therapeutics, Whitaker Cardiovascular Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States

2. Department of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, United States

3. Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States

Abstract

NCC regulation is sex dependent. In normotensive male and female Sprague-Dawley and Dahl salt-resistant rats, which exhibit dietary Na+-evoked NCC suppression, male rats exhibit decreased WNK4 expression and decreased SPAK and OxSR1 levels, whereas female rats only suppress SPAK and OxSR1. In hypertensive Dahl salt-sensitive rats, the ability of females to suppress NCC (in opposition to males) via a SPAK/OxSR1 mechanism likely contributes to their lower magnitude of salt-sensitive hypertension.

Funder

HHS | NIH | National Institute on Aging

Hevolution Foundation

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00150.2023

Reference52 articles.

1. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people

2. Prehypertension and Incidence of ESRD: A Systematic Review and Meta-analysis

3. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

4. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

5. Sodium Intake and Hypertension

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