Muscle blood flow and vasodilation are blunted at the onset of exercise following an acute bout of ischemia-reperfusion

Author:

Hanson Brady E.1ORCID,Feider Andrew J.2,Hanada Satoshi2,Aldrich Aric W.2,Casey Darren P.134ORCID

Affiliation:

1. Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States

2. Department of Anesthesia, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States

3. Abboud Cardiovascular Research Center, University of Iowa, Iowa City, Iowa, United States

4. Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, United States

Abstract

Ischemia-reperfusion can impair endothelial function; however, it remains unknown whether exercise hyperemia and vasodilation are also impaired. This study presents novel findings that ischemia-reperfusion blunts the hyperemic and vasodilatory responses at the onset of muscle contractions but not during steady-state exercise. Plasma [nitrite] was also blunted at baseline and during steady-state exercise following ischemia-reperfusion compared with time control. These attenuated responses at the onset of exercise may be associated with ischemia-reperfusion reductions in NO bioavailability.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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