Lumbar muscle atrophy and increased relative intramuscular lipid concentration are not mitigated by daily artificial gravity after 60-day head-down tilt bed rest-Reference-Cited by-同舟云学术

Lumbar muscle atrophy and increased relative intramuscular lipid concentration are not mitigated by daily artificial gravity after 60-day head-down tilt bed rest

Published:2021-07-01 Issue:1 Volume:131 Page:356-368
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

De Martino Enrico¹^ORCID,Hides Julie²^ORCID,Elliott James M.³⁴^ORCID,Hoggarth Mark³⁵,Zange Jochen⁶^ORCID,Lindsay Kirsty¹^ORCID,Debuse Dorothée¹,Winnard Andrew¹^ORCID,Beard David⁷^ORCID,Cook Jonathan A.⁷⁸^ORCID,Salomoni Sauro E.⁹^ORCID,Weber Tobias¹⁰¹¹^ORCID,Scott Jonathan¹⁰¹¹,Hodges Paul W.⁹^ORCID,Caplan Nick¹^ORCID

Affiliation:

1. Aerospace Medicine and Rehabilitation Laboratory, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, United Kingdom

2. School of Allied Health Sciences, Griffith University, Nathan Campus, Brisbane, Queensland, Australia

3. Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine Northwestern University, Chicago, Illinois

4. Kolling Research Institute, Faculty of Medicine and Health, The University of Sydney and Northern Sydney Local Health District, Sydney, New South Wales, Australia

5. Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois

6. Institute of Aerospace Medicine, German Aerospace Center (DLR), Cologne, Germany

7. NIHR Oxford Biomedical Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom

8. Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom

9. NHMRC Centre for Clinical Research Excellence in Spinal Pain, Injury and Health, School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia

10. European Astronaut Centre, Space Medicine Team (HRE-OM), European Space Agency (ESA), Cologne, Germany

11. KBR GmbH, Cologne, Germany

Abstract

This study presents novel insights into the morphological adaptations occurring in the lumbar spine after 60-day head-down bed rest and the potential role of artificial gravity (AG) to mitigate them. Results demonstrated no protective effect of AG protocols used in this study. In atrophied paraspinal muscles, the ratio of lipids versus intramuscular water increased in the postural lumbar muscles, which could impair muscle function during upright standing. These findings have relevance for future space explorations.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

UKRI | Science and Technology Facilities Council

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00990.2020

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