Airway tree caliber heterogeneity and airflow obstruction among older adults-Reference-Cited by-同舟云学术

Airway tree caliber heterogeneity and airflow obstruction among older adults

Published:2024-05-01 Issue:5 Volume:136 Page:1144-1156
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Vameghestahbanati Motahareh¹^ORCID,Kingdom Leina¹,Hoffman Eric A.²^ORCID,Kirby Miranda³,Allen Norrina B.⁴,Angelini Elsa⁵⁶,Bertoni Alain⁷,Hamid Qutayba¹⁸,Hogg James C.⁹,Jacobs David R.¹⁰,Laine Andrew⁶^ORCID,Maltais Francois¹¹,Michos Erin D.¹²,Sack Coralynn¹³,Sin Don⁹^ORCID,Watson Karol E.¹⁴,Wysoczanksi Artur⁶,Couper David¹⁵,Cooper Christopher¹⁴^ORCID,Han Meilan¹⁶,Woodruff Prescott¹⁷,Tan Wan C.⁹,Bourbeau Jean¹,Barr R. Graham⁶,Smith Benjamin M.¹⁶^ORCID,

Affiliation:

1. Department of Medicine, McGill University, Montreal, Quebec, Canada

2. Department of Radiology, University of Iowa, Iowa City, Iowa, United States

3. Department of Physics, Ryerson University, Toronto, Ontario, Canada

4. Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University, Chicago, Illinois, United States

5. Faculty of Medicine, Imperial College London, London, United Kingdom

6. Department of Medicine, Columbia University, New York, New York, United States

7. Department of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, United States

8. Faculty of Medicine, University of Sharjah, Sharjah, United Arab Emirates

9. Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada

10. School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States

11. Faculty of Medicine , University of Laval, Laval, Quebec, Canada

12. Faculty of Medicine, Johns Hopkins University, Baltimore, Maryland, United States

13. Department of Medicine, University of Washington, Seattle, Washington, United States

14. Department of Medicine, University of California, Los Angeles, California, United States

15. Department of Biostatistics, University of North Carolina, North Carolina, United States

16. Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, United States

17. Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, California, United States

Abstract

In this study, by leveraging two community-based samples and a case-control study of heavy smokers, we show that among older adults, airway tree caliber heterogeneity quantified by CT is associated with airflow obstruction and COPD independent of age, sex, height, race-ethnicity, and dysanapsis. These observations suggest that airway tree caliber heterogeneity is a structural trait associated with low baseline lung function and normal decline trajectory that is relevant to COPD.

Funder

Vanier Canada Graduate Scholarship

Gouvernement du Canada | Canadian Institutes of Health Research

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00694.2022

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