ASICs are required for immediate exercise-induced muscle pain and are downregulated in sensory neurons by exercise training-Reference-Cited by-同舟云学术

ASICs are required for immediate exercise-induced muscle pain and are downregulated in sensory neurons by exercise training

Published:2020-07-01 Issue:1 Volume:129 Page:17-26
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Khataei Tahsin¹²³^ORCID,Harding Anne Marie S.²³,Janahmadi Mahyar⁴,El-Geneidy Maram²³,Agha-Alinejad Hamid¹,Rajabi Hamid⁵,Snyder Peter M.²³,Sluka Kathleen A.⁶⁷,Benson Christopher J.²³⁸

Affiliation:

1. Department of Exercise Physiology, Tarbiat Modares University, Tehran, Iran

2. Department of Internal Medicine, University of Iowa, Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa

3. Iowa City Veterans Affairs Healthcare System, Iowa City, Iowa

4. Department of Physiology and Neuroscience Research Center, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5. Department of Exercise Physiology, Kharazmi University, Tehran, Iran

6. Department of Physical Therapy and Rehabilitation Science, The University of Iowa, Iowa City, Iowa

7. Neuroscience Institute, The University of Iowa, Iowa City, Iowa

8. Department of Pharmacology, University of Iowa, Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa

Abstract

Exercise performance can be limited by the sensations of muscle fatigue and pain transmitted by muscle afferents. It has been proposed that exercise training abrogates these negative feedback signals. We found that acid-sensing ion channels (ASICs) are required for immediate exercise-induced muscle pain (IEIP). Moreover, exercise training prevented IEIP and was correlated with downregulation of ASICs in sensory neurons.

Funder

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00033.2020

Reference55 articles.

1. Modulation of ASIC channels in rat cerebellar purkinje neurons by ischaemia‐related signals

2. Implications of group III and IV muscle afferents for high-intensity endurance exercise performance in humans

3. Lactate and H+ effluxes from human skeletal muscles during intense, dynamic exercise.