Graded lower body negative pressure induces intraventricular negative pressures and incremental diastolic suction: a pressure-volume study in a porcine model-Reference-Cited by-同舟云学术

Graded lower body negative pressure induces intraventricular negative pressures and incremental diastolic suction: a pressure-volume study in a porcine model

Published:2022-07-01 Issue:1 Volume:133 Page:20-26
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Berboth Leonhard¹^ORCID,Zirngast Birgit²,Manninger Martin³,Steendijk Paul⁴,Tschöpe Carsten¹,Scherr Daniel³,Hinghofer-Szalkay Helmut G.⁵,Goswami Nandu⁵⁶^ORCID,Petersen Lonnie G.⁷⁸^ORCID,Mächler Heinrich²,Alogna Alessio¹⁹¹⁰^ORCID

Affiliation:

1. Department of Internal Medicine and Cardiology, Charité—Universitätsmedizin Berlin, Berlin, Germany

2. Department of Cardiac Surgery, Medical University of Graz, Graz, Austria

3. Department of Cardiology, University Clinic of Medicine, Medical University of Graz, Graz, Austria

4. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

5. Institute of Physiology, Centre of Physiological Medicine, Medical University of Graz, Graz, Austria

6. Mohammed Bin Rashid University of Medicine and Health Science, Dubai Healthcare City, Dubai, United Arab Emirates

7. Department of Radiology, University of California, San Diego, California

8. Mechanical and Aerospace Engineering, University of California, San Diego, California

9. Berlin Institute of Health, Charité—Universitätsmedizin Berlin, Berlin, Germany

10. DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany

Abstract

This study examined the effects of incremental lower body negative pressure (LBNP) from −15 to −45 mmHg on hemodynamic regulation using invasive pressure-volume assessment in closed-chest pigs. Graded preload reduction via LBNP induces negative left ventricular (LV) pressures while increasing LV suction and thus allowing the ventricle to eject below the equilibrium volume at the end of systole. Accordingly, LBNP-induced central hypovolemia is associated with increased diastolic suction.

Funder

K.H. Tscheliessnigg Foundation

Berlin Institute of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00110.2022

Reference34 articles.

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2. Lower body negative pressure as a model to study progression to acute hemorrhagic shock in humans

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