Bilateral nephrectomy impairs cardiovascular function and cerebral perfusion in a rat model of acute hemodilutional anemia-Reference-Cited by-同舟云学术

Bilateral nephrectomy impairs cardiovascular function and cerebral perfusion in a rat model of acute hemodilutional anemia

Published:2024-05-01 Issue:5 Volume:136 Page:1245-1259
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Chin Kyle¹²,Jiang Helen¹²,Steinberg Benjamin E.²³⁴^ORCID,Goldenberg Neil M.²³⁴^ORCID,Desjardins Jean-Francois⁵⁶,Kabir Golam⁵⁶,Liu Elaine¹⁵,Vanama Ramesh³,Baker Andrew J.¹⁵⁷,Deschamps Alain⁸,Simpson Jeremy A.⁹¹⁰^ORCID,Maynes Jason T.³⁴¹¹^ORCID,Vinogradov Sergei A.¹²,Connelly Kim A.²⁶^ORCID,Mazer C. David¹²⁴⁷¹³^ORCID,Hare Gregory M. T.¹²⁴⁵¹⁰^ORCID

Affiliation:

1. Department of Anesthesiology and Pain Medicine, St Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada

2. Department of Physiology, University of Toronto, Toronto, Ontario, Canada

3. Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada

4. Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada

5. Keenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada

6. Division of Cardiology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

7. Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

8. Institut de Cardiologie de Montréal, Université de Montréal, Montreal Quebec, Canada

9. Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada

10. IMPART investigator team Canada (), Saint John, New Brunswick, Canada

11. Program in Molecular Medicine, Hospital for Sick Children’s Research Institute, Toronto, Ontario, Canada

12. Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States

13. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada

Abstract

This study has demonstrated that bilateral nephrectomy acutely impaired cardiac output (CO) and microvascular brain Po2 (PBro2), at baseline. Following acute hemodilution, nephrectomy prevented the adaptive increase in CO associated with acute hemodilution leading to a further reduction in PBro2, accentuating the degree of cerebral tissue hypoxia. These data support a role for the kidney in maintaining PBro2 and initiating the increase in CO that optimized brain perfusion during acute anemia.

Funder

CAS RA Gordon Award

University of Toronto, Department of Anesthesia and Pain Medicine Merit Award

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00858.2023

Reference58 articles.

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5. Acute Surgical Anemia Influences the Cardioprotective Effects of β-Blockade