Sympathetic structural and electrophysiological remodeling in a rabbit model of reperfused myocardial infarction-Reference-Cited by-同舟云学术

Sympathetic structural and electrophysiological remodeling in a rabbit model of reperfused myocardial infarction

Published:2024-09-01 Issue:3 Volume:327 Page:H631-H638
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Guevara Amanda¹^ORCID,Smith Charlotte E. R.¹^ORCID,Wang Lianguo¹^ORCID,Caldwell Jessica L.¹^ORCID,Tapa Srinivas¹^ORCID,Francis Stuart Samantha D.¹,Ma Betty W.²,Ng G. Andre³⁴⁵^ORCID,Habecker Beth A.⁶⁷^ORCID,Wang Zhen¹⁸,Ripplinger Crystal M.¹^ORCID

Affiliation:

1. Department of Pharmacology, University of California Davis, Davis, California, United States

2. Campus Veterinary Services, University of California Davis, Davis, California, United States

3. Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom

4. National Institute for Health & Care Research, Leicester Biomedical Research Centre, Leicester, United Kingdom

5. Glenfield Hospital, Leicester, United Kingdom

6. Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, United States

7. Department of Medicine and Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, United States

8. Shantou University Medical College, Shantou, China

Abstract

Here, we show that CSPGs are present in the infarcts of rabbit hearts with reperfused MI, where they are associated with reduced sympathetic nerve density. Despite hypoinnervation, sympathetic responsiveness is maintained or enhanced in MI rabbit hearts, which also demonstrate increased APD dispersion and tendency for arrhythmias following sympathetic modulation. Together, this study indicates that the mechanisms of sympathetic remodeling post-MI are similar between rodents and rabbits, with hypoinnervation likely associated with enhanced β-adrenergic sensitivity.

Funder

广东省人民政府 | National Natural Science Foundation of China-Guangdong Joint Fund

British Heart Foundation

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of General Medical Sciences

UKRI | Medical Research Council

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00398.2024

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5. Impaired Cardiac Sympathetic Innervation and Myocardial Perfusion Are Related to Lethal Arrhythmia: Quantification of Cardiac Tracers in Patients with ICDs