Common carotid artery responses to the cold-pressor test are impaired in individuals with cervical spinal cord injury

Author:

Sarafis Zoe K.1ORCID,Squair Jordan W.1234,Barak Otto F.5,Coombs Geoff B.6ORCID,Soriano Jan Elaine2ORCID,Larkin-Kaiser Kelly A.2ORCID,Lee Amanda H. X.14ORCID,Hansen Alex7ORCID,Vodopic Maro8,Romac Rinaldo9,Grant Christopher10,Charbonneau Rebecca10,Mijacika Tanja11,Krassioukov Andrei V.11213,Ainslie Philip N.6,Dujic Zeljko11,Phillips Aaron A.2ORCID

Affiliation:

1. International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

2. RESTORE.network, Departments of Physiology and Pharmacology, Cardiac Sciences and Clinical Neurosciences, Biomedical Engineering, Libin Cardiovascular Institute of Alberta, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada

3. MD/PhD Training Program, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

4. Department of Experimental Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

5. Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia

6. Centre for Heart, Lung and Vascular Health, University of British Columbia Okanagan, Kelowna, British Columbia, Canada

7. Department of Sport Science, University of Innsbruck, Innsbruck, Austria

8. Department of Neurology, General Hospital, Dubrovnik, Croatia

9. Department of Neurology, Clinical Hospital Center, Split, Croatia

10. Division of Physical Medicine and Rehabilitation, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

11. Department of Integrative Physiology, University of Split School of Medicine, Split, Croatia

12. Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, British Columbia, Canada

13. GF Strong Rehabilitation Centre, Vancouver, British Columbia, Canada

Abstract

This is the first study demonstrating that CCA responses during CPT are suppressed in SCI. Specifically, CCA diameter, flow, velocity, and shear rate were reduced. The relationship between changes in MAP and CCA dilatation in response to CPT was absent in individuals with SCI, despite similar cardiovascular activation between SCI and uninjured controls. These findings support the notion of elevated cardiovascular disease risk in SCI and that the cardiovascular responses to environmental stimuli are impaired.

Funder

RESTORE.network

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council

Blusson Integrated Cures Partnership

Canada Research Chair

Wings for Life

Digital Research Alliance of Canada

Libin Cardiovascular Institute of Alberta

Hotchkiss Brain Institute

PRAXIS

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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