Common carotid artery responses to the cold-pressor test are impaired in individuals with cervical spinal cord injury

Author:

Sarafis Zoe K.1ORCID,Squair Jordan W.1234,Barak Otto F.5,Coombs Geoff B.6ORCID,Soriano Jan Elaine2ORCID,Larkin-Kaiser Kelly A.2ORCID,Lee Amanda H. X.14ORCID,Hansen Alex7ORCID,Vodopic Maro8,Romac Rinaldo9,Grant Christopher10,Charbonneau Rebecca10,Mijacika Tanja11,Krassioukov Andrei V.11213,Ainslie Philip N.6,Dujic Zeljko11,Phillips Aaron A.2ORCID

Affiliation:

1. International Collaboration on Repair Discoveries, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

2. RESTORE.network, Departments of Physiology and Pharmacology, Cardiac Sciences and Clinical Neurosciences, Biomedical Engineering, Libin Cardiovascular Institute of Alberta, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada

3. MD/PhD Training Program, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

4. Department of Experimental Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

5. Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia

6. Centre for Heart, Lung and Vascular Health, University of British Columbia Okanagan, Kelowna, British Columbia, Canada

7. Department of Sport Science, University of Innsbruck, Innsbruck, Austria

8. Department of Neurology, General Hospital, Dubrovnik, Croatia

9. Department of Neurology, Clinical Hospital Center, Split, Croatia

10. Division of Physical Medicine and Rehabilitation, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

11. Department of Integrative Physiology, University of Split School of Medicine, Split, Croatia

12. Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, British Columbia, Canada

13. GF Strong Rehabilitation Centre, Vancouver, British Columbia, Canada

Abstract

This is the first study demonstrating that CCA responses during CPT are suppressed in SCI. Specifically, CCA diameter, flow, velocity, and shear rate were reduced. The relationship between changes in MAP and CCA dilatation in response to CPT was absent in individuals with SCI, despite similar cardiovascular activation between SCI and uninjured controls. These findings support the notion of elevated cardiovascular disease risk in SCI and that the cardiovascular responses to environmental stimuli are impaired.

Funder

RESTORE.network

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council

Blusson Integrated Cures Partnership

Canada Research Chair

Wings for Life

Digital Research Alliance of Canada

Libin Cardiovascular Institute of Alberta

Hotchkiss Brain Institute

PRAXIS

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3