Rhythm dynamics of the aging heart: an experimental study using conscious, restrained mice-Reference-Cited by-同舟云学术

Rhythm dynamics of the aging heart: an experimental study using conscious, restrained mice

Published:2020-10-01 Issue:4 Volume:319 Page:H893-H905
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Comelli Martina¹,Meo Marianna²,Cervantes Daniel O.¹,Pizzo Emanuele¹,Plosker Aaron¹,Mohler Peter J.³⁴⁵,Hund Thomas J.³⁵⁶,Jacobson Jason T.¹⁷,Meste Olivier⁸,Rota Marcello¹^ORCID

Affiliation:

1. Department of Physiology, New York Medical College, Valhalla, New York

2. IHU Liryc, Electrophysiology and Heart Modeling Institute, Bordeaux University Foundation, F-33600 Pessac-Bordeaux, France, with Univ. Bordeaux and INSERM, CRCTB, U1045, Bordeaux, France

3. The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio

4. Department of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, Ohio

5. Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio

6. Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, Ohio

7. Division of Cardiology, Department of Medicine, Westchester Medical Center, New York Medical College, Valhalla, New York

8. Laboratoire d'Informatique, Signaux et Systèmes de Sophia Antipolis, Université Côte d’Azur, CNRS, I3S, France

Abstract

We have investigated age-associated alterations of heart rate properties in mice using conscious electrocardiographic recordings. Our findings support the notion that aging is coupled with altered sympathovagal balance with consequences on heart rate variability. Moreover, by using a genetically engineered mouse line, we provide evidence that sodium channels modulate heart rate and its age-related adaptations.

Funder

HHS | National Institutes of Health

American Heart Association

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00379.2020

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