GPER-dependent estrogen signaling increases cardiac GCN5L1 expression-Reference-Cited by-同舟云学术

GPER-dependent estrogen signaling increases cardiac GCN5L1 expression

Published:2022-05-01 Issue:5 Volume:322 Page:H762-H768
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Manning Janet R.¹²³^ORCID,Thapa Dharendra¹²³^ORCID,Zhang Manling¹²³,Stoner Michael W.¹²³,Sembrat John C.⁴,Rojas Mauricio⁵^ORCID,Scott Iain¹²³^ORCID

Affiliation:

1. Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

2. Department of Medicine, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania

3. Department of Medicine, Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

4. Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

5. Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio

Abstract

We demonstrate here for the first time that mitochondrial protein acetylation is increased in female hearts, associated with an increase in GCN5L1 levels through a GPER-dependent mechanism. These findings reveal a new potential mediator of divergent cardiac mitochondrial function between men and women.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

University of Pittsburgh

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00024.2022

Reference41 articles.

1. The Role of Estrogen Receptors in Cardiovascular Disease

2. The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function