CaMKIIδ Met281/282 oxidation is not required for recovery of calcium transients during acidosis-Reference-Cited by-同舟云学术

CaMKIIδ Met281/282 oxidation is not required for recovery of calcium transients during acidosis

Published:2021-03-01 Issue:3 Volume:320 Page:H1199-H1212
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Kreitmeier K. G.¹²^ORCID,Tarnowski D.¹,Nanadikar M. S.³,Baier M. J.¹^ORCID,Wagner S.¹,Katschinski D. M.³^ORCID,Maier L. S.¹,Sag C. M.¹

Affiliation:

1. Department of Internal Medicine II, University Medical Center Regensburg, Germany

2. Department of Internal Medicine III, University Medical Center Regensburg, Germany

3. Institute for Cardiovascular Physiology, Georg August University, Göttingen, Germany

Abstract

The current study shows that activation of CaMKIIδ through Met281/282 oxidation is neither required for CaMKII-dependent recovery of Ca2+ transients during acidosis nor relevant for the occurrence of postacidic cellular arrhythmias. Despite a usually prooxidant increase in cytosolic Na+, acidosis reduces the cytosolic glutathione redox state within cardiac myocytes. This novel finding suggests that oxidation of cytosolic proteins is less likely to occur during acidosis.

Funder

Deutsche Gesellschaft für Kardiologie

Deutsche Forschungsgemeinschaft

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00040.2020

Reference58 articles.

1. Myocardial ischemia-reperfusion injury: a neglected therapeutic target

2. Ca2+/calmodulin-dependent protein kinase: A key component in the contractile recovery from acidosis

3. Inhibition of the activation and troponin calcium binding of dog cardiac myofibrils by acidic pH.

4. Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles.

5. The effects of changes of pH on intracellular calcium transients in mammalian cardiac muscle.

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