Affiliation:
1. Institut National de la Santé et de la Recherche Médicale, U451-Loa-Ensta-Ecole Polytechnique, 91125 Palaiseau Cédex; Service de Physiologie Cardio-Respiratoire, Université de Paris XI, Hôpital de Bicêtre, 94275 Le Kremlin Bicêtre; and Service de Cardiologie, Hôpital Antoine-Béclère, 92141 Clamart, France
Abstract
On the basis of the windkessel model, the stroke volume-to-aortic pulse pressure ratio (SV/PP) has been proposed as an estimate of total arterial compliance, but recent studies have questioned this approximation. Aortic pressure was obtained at rest in 31 adults undergoing cardiac catheterization (47 ± 14 yr): controls ( n = 7), patients with dilated cardiomyopathy ( n = 10), and patients with other cardiac diseases ( n = 14). We calculated PP, mean aortic pressure (MAoP), heart period ( T), SV (thermodilution cardiac output/heart rate), total peripheral resistance ( R), total arterial compliance estimated by area method ( Carea), and the time constant of aortic pressure decay in diastole ( RCarea). In the overall population ( n = 31), there was no significant difference between SV/PP and Carea. SV/PP was linearly related to Carea(SV/PP = 0.99 Carea+ 0.05; r = 0.98; P < 0.001); the slope and intercept did not differ from unity and zero, respectively. Similar results were obtained in the three subgroups. These results implied that PP/MAoP and T/ RCareawere proportionally related ( T/ RCarea= 1.18PP/MAoP − 0.07; r = 0.96; P < 0.001). We conclude that for humans at rest 1) SV/PP gave a reliable estimate of Carea, and 2) T normalized by the time constant of aortic pressure decay in diastole was proportionally related to PP/MAoP. This last relationship could be considered an aspect of the coupling between the left ventricle and its load.
Publisher
American Physiological Society
Subject
Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology
Cited by
338 articles.
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