Irx5 and transient outward K<sup>+</sup> currents contribute to transmural contractile heterogeneities in the mouse ventricle-Reference-Cited by-同舟云学术

Irx5 and transient outward K⁺ currents contribute to transmural contractile heterogeneities in the mouse ventricle

Published:2022-05-01 Issue:5 Volume:322 Page:H725-H741
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Kim Kyoung-Han¹²³^ORCID,Oh Yena¹²,Liu Jie³⁴,Dababneh Saif¹^ORCID,Xia Ying¹²,Kim Ri Youn¹²,Kim Dae-Kyum⁵^ORCID,Ban Kiwon³⁶,Husain Mansoor³⁷,Hui Chi-Chung⁸⁹,Backx Peter H.⁴⁷

Affiliation:

1. University of Ottawa Heart Institute, Ottawa, Ontario, Canada

2. Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada

3. Department of Physiology, University of Toronto, Toronto, Ontario, Canada

4. Department of Biology, Faculty of Science, York University, Toronto, Ontario, Canada

5. Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, New York

6. Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, People’s Republic of China

7. Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada

8. Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada

9. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

Abstract

Irx5 is a vital transcription factor that establishes the transmural heterogeneity of ventricular myocyte contractility, thereby ensuring proper contractile function in the healthy heart. Regional differences in excitation-contraction coupling in the ventricular myocardium are primarily mediated through the inverse relationship between Irx5 and the fast transient outward K+ current ( Ito,f) across the ventricular wall.

Funder

Gouvernement du Canada | Canadian Institutes of Health Research

Heart and Stroke Foundation of Canada

National Research Foundation of Korea

University of Ottawa Heart Institute Foundation

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00572.2021