Mechanical response of cardiac microtissues to acute localized injury-Reference-Cited by-同舟云学术

Mechanical response of cardiac microtissues to acute localized injury

Published:2022-10-01 Issue:4 Volume:323 Page:H738-H748
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Das Shoshana L.¹²³^ORCID,Sutherland Bryan P.²³,Lejeune Emma⁴^ORCID,Eyckmans Jeroen²³,Chen Christopher S.²³^ORCID

Affiliation:

1. Harvard-MIT Program in Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts

2. Department of Biomedical Engineering, Boston University, Boston, Massachusetts

3. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts

4. Department of Mechanical Engineering, Boston University, Boston, Massachusetts

Abstract

We report an in vitro cardiac injury model that uses a high-powered laser to induce regional cell death and a focal fibrotic response within a human-engineered cardiac microtissue. The model captures the effects of acute injury on tissue response, remodeling, and electromechanical recovery in both the damaged region and surrounding healthy tissue, modeling similar changes to contractile function observed in vivo following myocardial infarction.

Funder

American Heart Association

HHS | NIH | National Institute of Biomedical Imaging and Bioengineering

National Science Foundation

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00305.2022

Reference60 articles.

1. Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration