Age and sex hormones modulate left ventricle regional response to angiotensin II in male and female mice

Author:

Walsh-Wilkinson Élisabeth1,Aidara Mohamed Lamine1,Morin-Grandmont Audrey1,Thibodeau Sara-Ève1,Gagnon Juliette1,Genest Mathieu1,Arsenault Marie1,Couet Jacques1ORCID

Affiliation:

1. Groupe de recherche sur les valvulopathies, Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec City, Québec, Canada

Abstract

We propose a new method for the study of regional strain data by analyzing individually the software-generated 48 regions of interest (ROI) from an LV wall tracing in B-mode. This helps obtain a more comprehensive profile of strain data. Using these new tools, we studied in mice how sex, sex hormones, age, or a pathological stress influenced strain parameters. We show that for similar cardiac hypertrophy, regional strain shows important differences related to sex, sex hormones, and age.

Funder

Fondation Institut Universitaire de Cardiologie et de Pneumologie de Québec

Gouvernement du Canada | IRSC | Institute of Gender and Health

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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