Characterizing the influence of cardiorespiratory fitness on left atrial size and function in the general population-Reference-Cited by-同舟云学术

Characterizing the influence of cardiorespiratory fitness on left atrial size and function in the general population

Published:2024-05-01 Issue:5 Volume:326 Page:H1269-H1278
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Spencer Luke¹²^ORCID,Wright Leah³,Foulkes Stephen J.⁴,Rowe Stephanie J.¹²⁵,Dillon Hayley T.³⁶^ORCID,Climie Rachel⁷,Bigaran Ashley⁸,Janssens Kristel¹⁹^ORCID,Mitchell Amy¹^ORCID,Wallace Imogen³^ORCID,Lindqvist Anniina³,Burnham Lauren³,Prior David L.⁵^ORCID,Howden Erin J.²³^ORCID,La Gerche Andre⁵¹⁰^ORCID

Affiliation:

1. St Vincent's Institute, Fitzroy, Victoria, Australia

2. University of Melbourne, Parkville, Victoria, Australia

3. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

4. University of Alberta, Edmonton, Alberta, Canada

5. Cardiology Department, St Vincent’s Hospital Melbourne, Fitzroy, Victoria, Australia

6. Deakin University, Geelong, Victoria, Australia

7. Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia

8. Austin Health, Heidelberg, Victoria, Australia

9. Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Fitzroy, Victoria, Australia

10. Victor Chang Cardiac Research Centre, Darlinghurst, New South Wales, Australia

Abstract

Left atrial (LA) structure better predicts cardiorespiratory fitness (CRF) than LA function. LA function adds little statistical value to predictive models of peak oxygen uptake (V̇o2peak) in healthy individuals, suggesting limited discriminatory for CRF once LA size is factored. In the wider population of ostensibly healthy individuals, the association between increased LA volume and higher CRF provides an important counter to the association between atrial enlargement and heart failure symptoms in those with cardiac pathology.

Funder

WCRF | World Cancer Research Fund

Australian Government Research Training Program Scholarship

DHAC | National Health and Medical Research Council

National Heart Foundation of Australia

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00422.2023

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