Muscarinic Receptor Binding of the Novel Radioligand, [3H]Imidafenacin in the Human Bladder and Parotid Gland

Author:

Yoshida Akira,Kuraoka Shiori,Ito Yoshihiko,Okura Takashi,Deguchi Yoshiharu,Otsuka Atsushi,Ozono Seiichiro,Takeda Masayuki,Masuyama Keisuke,Araki Isao,Yamada Shizuo

Publisher

Japanese Pharmacological Society

Subject

Pharmacology,Molecular Medicine

Reference23 articles.

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2. 2 Finney SM, Andersson KE, Gillespie JI, Stewart LH. Antimuscarinic drugs in detrusor overactivity and the overactive bladder syndrome: motor or sensory actions? BJU Int. 2006;98:503–507.

3. 3 Yoshida A, Fujino T, Maruyama S, Ito Y, Taki Y, Yamada S. The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: bladder selectivity based on in vivo drug-recetor binding characteristics of antimuscarinic agents for treatment of overactive bladder. J Pharmacol Sci. 2010;112:142–150.

4. 4 Kobayashi F, Yageta Y, Segawa M, Matsuzawa S. Effects of imidafenacin (IMIDAFENACIN-197/ONO-8025), a new anti-cholinergic agent, on muscarinic acetylcholine receptors. High affinities for M3 and M1 receptor subtypes and selectivity for urinary bladder over salivary gland. Arzneimittelforschung. 2007;57:92–100.

5. 5 Kobayashi F, Yageta Y, Yamazaki T, Wakabayashi E, Inoue M, Segawa M, et al. Pharmacological effects of imidafenacin (IMIDAFENACIN-197/ONO-8025), a new bladder selective anti-cholinergic agent, in rats. Comparison of effects on urinary bladder capacity and contraction, salivary secretion and performance in the Morris water maze task. Arzneimittelforschung. 2007;57:147–154.

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