Author:
Yıkılmaz Aysun Şentürk,Bakanay Şule Mine,Akinci Sema,Alisik Murat,Erel Özcan,Dilek İmdat
Abstract
Summary
Background
This study aimed to show the status of thioldisulphide homeostasis in essential thrombocytosis patients, which is known to play a role in platelet function.
Methods
The study included 27 ET patients and a control group of 36 healthy subjects. Serum total (–SH + –S–S–) and native (–SH) thiol levels were measured in all subjects using an automatic method.
Results
Age and gender distribution were similar in both groups. Compared with the control group, in the ET group, there were increased native thiol and total thiol levels (p = 0.001, p = 0.046). There was no correlation between thiol, total thiol and disulphide ratios with Jak2 mutation, hemorrhage and thrombosis. A positive correlation was determined between thrombosis and thiol disulphide homeostasis (p = 0.058). The study results showed that thiol-disulphide homeostasis shifted to the proliferative side in ET, in which ineffective erythropoiesis was predominant. It is also known that platelets are more active in ET cases and thiol disulphide balance is important in platelet function.
Conclusions
This result suggests that thrombotic complications may be reduced if the formation is achieved of mechanisms (oxidation mechanisms) that will trigger the increase of disulphide groups. However, more extensive research is needed on this subject.
Publisher
Centre for Evaluation in Education and Science (CEON/CEES)
Reference64 articles.
1. Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma;Anal Biochem,1992
2. Bleeding time and platelet function in essential thrombocythemia and other myeloproliferative syndromes;Leuk Lymphoma,1996
3. Pathophysiology and treatment of platelet-mediated microvascular disturbances, major thrombosis and bleeding complications in essential thrombocythaemia and polycythaemia vera;Platelets,2004
4. Molecular and cellular aspects of thiol– disulfide exchange;Adv Enzymol Relat Areas Mol Biol,1990
5. Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity;Gut,1988
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献