Affiliation:
1. 1Pharmacology Department, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Abstract
AbstractThis article reviews a population pharmacokinetics studies conducted during the past few years in Serbia. Studies have included three the most frequently used antiepileptic drugs (valproate, carbamazepine and lamotrigine) and different populations of epileptic patients: children, adults and heterogeneous population composed of both children and adults. The review compares obtained values of population pharmacokinetic models of clearance of these drugs, and factors that are significantly determined, making brief comments on the results of other authors on the same topic. Individualization of drug dosage is the basis of rational therapy, and factors of variability will always be subject of scientific research.
Reference56 articles.
1. Williams P.J., Ette E.I., The role of population pharmacokinetics in drug development in light of the Food and Drug Administration’s ‘Guidance for Industry: Population Pharmacokinetics’, Clin. Pharmacokinet., 2000, 39, 385–395
2. Milovanovic J.R., Jankovic S.M., Population pharmacokinetics, Vojnosanit. Pregl., 2005, 11, 847–850 (in Serbian)
3. Beal S.L., Sheiner L.B., NONMEM Users Guides. NONMEM Project Group, University of San Francisko, San Francisko, CA, 1998
4. Aarons L., Software for population pharmacokinetics and pharmacodinamics, Clin. Pharmacokinet., 1999, 36, 255–264
5. Milovanović J.R., Antiepileptic drugs and population pharmacokinetics, Foundation Andrejevic, Belgrade, Serbia, 2009 (in Serbian)
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