Risk Factors for Weaning Failure in COVID-19 Patients

Author:

Gerovasileiou Effrosyni1,Menis Apostolis-Alkiviadis2,Gavriilidis George3,Magira Eleni4,Temperikidis Prodromos5,Papoti Sofia2,Karavidas Nikitas1,Spanos Michael1,Zakynthinos Epaminondas6,Makris Demosthenes1

Affiliation:

1. University Hospital of Larissa , Larissa , Greece

2. G. Papanikolaou Hospital , Thessaloniki , Greece

3. Sotiria Regional Chest Disease Hospital of Athens , Athens , Greece

4. Evangelismos Athens General Hospital , Athens , Greece

5. Evangelismos Athens General Hospital, Cardiology , Athens , Greece

6. General University Hospital of Larissa , Larissa , Greece

Abstract

Abstract Background Data on risk factors associated with mechanical ventilation (MV) weaning failure among SARS-CoV2 ARDS patients is limited. We aimed to determine clinical characteristics associated with weaning outcome in SARS-CoV2 ARDS patients under MV. Objectives To determine potential risk factors for weaning outcome in patients with SARS-CoV2 ARDS. Methods A retrospective observational study was conducted in the ICUs of four Greek hospitals via review of the electronic medical record for the period 2020–2021. All consecutive adult patients were screened and were included if they fulfilled the following criteria: a) age equal or above 18 years, b) need for MV for more than 48 hours and c) diagnosis of ARDS due to SARS-CoV2 pneumonia or primary or secondary ARDS of other aetiologies. Patient demographic and clinical characteristics were recorded for the first 28 days following ICU admission. The primary outcome was weaning success defined as spontaneous ventilation for more than 48 hours. Results A hundred and fifty eight patients were included; 96 SARS-CoV2 ARDS patients. SOFA score, Chronic Obstructive Pulmonary Disease (COPD) and shock were independently associated with the weaning outcome OR(95% CI), 0.86 (0.73–0.99), 0.27 (0.08–0.89) and 0.30 (0.14–0.61), respectively]. When we analysed data from SARS-CoV2 ARDS patients separately, COPD [0.18 (0.03–0.96)] and shock [0.33(0.12 – 0.86)] were independently associated with the weaning outcome. Conclusions The presence of COPD and shock are potential risk factors for adverse weaning outcome in SARS-CoV2 ARDS patients.

Publisher

Walter de Gruyter GmbH

Subject

General Mathematics

Reference43 articles.

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