Anti-A and anti-B titers, age, gender, biochemical parameters, and body mass index in Japanese blood donors-Reference-Cited by-同舟云学术

Anti-A and anti-B titers, age, gender, biochemical parameters, and body mass index in Japanese blood donors

Published:2023-12-01 Issue:4 Volume:39 Page:155-165
ISSN:1930-3955
Container-title:Immunohematology
language:en
Short-container-title:

Author:

Mikame M.¹,Tsuno N.H.²,Miura Y.³,Kitazaki H.³,Uchimura D.³,Miyagi T.⁴,Miyazaki T.⁵,Onodera T.⁶,Ohashi W.⁷,Kameda T.⁸,Ohkawa R.⁹,Kino S.¹⁰,Muroi K.¹¹

Affiliation:

1. Development Researcher, Japanese Red Cross Kanto-Koshinetsu Block Blood Center, and Central Blood Institute, Clinical Bioanalysis and Molecular Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , 2-1-67, Tatsumi, Koto-ku , Tokyo , , Japan

2. Deputy General Manager, Japanese Red Cross Kanto-Koshinetsu Block Blood Center, and Central Blood Institute , Tokyo , Japan

3. Clinical Laboratory Staff, Japanese Red Cross Hokkaido Block Blood Center , Hokkaido , Japan

4. Section Head, Japanese Red Cross Kanto-Koshinetsu Block Blood Center, and Central Blood Institute , Tokyo , Japan

5. Section Head, Japanese Red Cross Central Blood Institute , Tokyo , Japan

6. Head of Department, Japanese Red Cross Kanto-Koshinetsu Block Blood Center , Tokyo , Japan

7. Head of Department, Japanese Red Cross Hokkaido Block Blood Center , Hokkaido , Japan

8. Senior Lecturer, Department of Clinical Laboratory Science, Teikyo University, and Clinical Bioanalysis and Molecular Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo , Japan

9. Professor, Clinical Bioanalysis and Molecular Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Tokyo , Japan

10. General Manager, Japanese Red Cross Hokkaido Block Blood Center , Hokkaido , Japan

11. General Manager, Japanese Red Cross Kanto-Koshinetsu Block Blood Center , Tokyo , Japan

Abstract

Abstract It has been reported that anti-A and anti-B (ABO antibody) titers decrease with age, but little is known about the association between ABO antibody titers and physiologic/biochemical parameters such as body mass index (BMI), gamma-glutamyl transpeptidase (GGT), and total cholesterol (T-Cho). We investigated the present situation of ABO antibody titers among healthy blood donors in Japan and the physiologic/biochemical factors that may be associated with changes in ABO antibody titers. Plasma from 7450 Japanese blood donors was tested for ABO antibody titers using ABO reverse typing reagents by an automated microplate system; donor samples were classified into low, middle, and high titers according to the agglutination results obtained with diluted plasma samples. Multivariate regression analysis was performed to analyze the association between ABO antibody titers and age, gender, biochemical parameters (alanine transaminase [ALT], GGT, globulin, T-Cho, and glycosylated albumin [GA]), and BMI according to the ABO blood groups. A significant correlation between ABO antibody titers and age/gender, except for gender in anti-A of blood group B donors, was observed. BMI showed significant but negative correlations with anti-A and anti-B (β = −0.085 and −0.062, respectively; p < 0.01) in blood group O donors. In addition, significant but negative correlations between GGT and T-Cho with anti-B of blood group A donors (β = −0.055 and −0.047, respectively; p < 0.05) were observed. Although differences existed among the ABO blood groups, ABO antibody titers seem to be associated with physiologic and biochemical parameters of healthy individuals.

Publisher

Walter de Gruyter GmbH

Subject

Hematology,General Medicine,Immunology and Allergy

Link

https://www.sciendo.com/pdf/10.2478/immunohematology-2023-023

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