Association between adiponectin andADIPOQ (rs 1501299)gene polymorphism in gestational diabetes mellitus patients

Abstract

AbstractIntroductionIn this study, we seek to determine the association between the polymorphism of theADIPOQ (rs1501299)gene and adiponectin levels in gestational diabetes mellitus (GDM) patients.MethodsThe study participants included 200 pregnant women, 100 healthy subjects as the control group, and 100 having GDM as the case group. The enzyme-linked immunosorbent assay (ELISA) was used to examine adiponectin levels. The polymerase chain reaction-restriction length polymorphism (PCR-RFLP) was also used for genotyping examination.ResultsFindings showed that GDM patients had significantly lower serum adiponectin levels (p=0.001). The T/T genotype ho-mozygotes prevalence for rs1501299 polymorphism was significantly lower in GDM patients. (p=0.047).ConclusionLow serum adiponectin levels are associated with GDM. The T allele of the rs1501299 (+276 G/T) polymorphism of the ADIPOQ gene protects against GDM.