Complexes of platinum and palladium with 4-nitrobenzoic hydrazide: synthesis and cytotoxic activity-Reference-Cited by-同舟云学术

Complexes of platinum and palladium with 4-nitrobenzoic hydrazide: synthesis and cytotoxic activity

Published:2013-02-01 Issue:2 Volume:11 Page:290-294
ISSN:2391-5420
Container-title:Open Chemistry
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Author:

Souza Gustavo¹,Rodrigues Mônica¹,Fernandes Lucianno¹,Silva Priscila²,Ruggiero Reinaldo¹,Pereira-Maia Elene²,Guerra Wendell¹

Affiliation:

1. 1Chemistry Institute, Federal University of Uberlândia, Campus Santa Mônica, 38, 400-902, Uberlândia — MG, Brazil

2. 2Chemistry Department, Federal University of Minas Gerais, Campus Pampulha, 31, 270-901, Belo Horizonte — MG, Brazil

Abstract

AbstractNew complexes of platinum and palladium were isolated with 4-nitrobenzoic hydrazide (4-NH) and characterized by spectroscopic techniques. Results show that the ligand is coordinated to metallic ions by the basic nitrogen of NH2 group and have the general structure cis-[M(4-NH)2X2] where M= Pt or Pd and x = Cl or I. The compound III, [Pt(4-NH)2I2], was found to display cytotoxicity (IC50 = 0.96 µmol L−1) against the K562 tumoral cell line. This complex is significantly more cytotoxic than cisplatin.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,General Chemistry

Link

http://link.springer.com/content/pdf/10.2478/s11532-012-0156-5.pdf

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