Prevalence of Hepatitis B in Random Bulgarian Blood Samples – A Single-Site Experience-Reference-Cited by-同舟云学术

Prevalence of Hepatitis B in Random Bulgarian Blood Samples – A Single-Site Experience

Published:2023-05-14 Issue:2 Volume:50 Page:5-9
ISSN:2719-5384
Container-title:Acta Medica Bulgarica
language:en
Short-container-title:

Author:

Gotseva A.¹,Naseva E.²

Affiliation:

1. 1 Laboratory of Virology , Military Medical Academy , Bulgaria

2. 2 Department of Health Economics, Faculty of Public Health „Prof. Tsekomir Vodenicharov , MD, DSc”, Medical University – Sofia , Bulgaria

Abstract

Abstract The worldwide distribution of the HBV infection has usually been estimated by the prevalence of hepatitis B surface antigen (HBsAg) among the general population. Total antibodies for hepatitis B core antigen (anti-HBc) are the most important diagnostic marker for proving prior exposure to HBV. Aim The aim of this study was to determine the prevalence of Hepatitis B virus (HBV) infection among Bulgarian population. Reliable epidemiologic data is needed to estimate the prevalence of Hepatitis B in order to determine the actual burden of the infection and to plan prevention and control measures. Materials and methods A total of 2140 serum samples were tested for major serological markers of HBV (HBsAg and anti-HBc) for a period of two years (2018-2019). Results We established an intermediate prevalence of HBsAg (5.1%) and high prevalence of anti-HBc (27%) among HBsAg negative individuals. Conclusion In conclusion, the prevalence of Hepatitis B is much higher among those born before the introduction of universal hepatitis B vaccination in Bulgaria (1992).

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/amb-2023-0013

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