Comparative Multimodal Palliative efficacy of gabapentin and tramadol By Using Two Pain Scoring Systems in Cats Undergoing Ovariohysterectomy

Author:

Rabbani Ameer Hamza1,Ullah Qudrat1,Naseer Omer2,Gardezi Faizan Haider3,Shahid Muhammad1,Hussain Kashif2,Saleem Taimoor4,Ali Ahmad2,Khan Yasir Razzaq2,Waheed Abdul5

Affiliation:

1. Department of Surgery, Faculty of Veterinary Sciences , Cholistan University of Veterinary and Animal Sciences , Bahawalpur , Pakistan

2. Department of Medicine, Faculty of Veterinary Sciences , Cholistan University of Veterinary and Animal Sciences , Bahawalpur , Pakistan

3. Department of Pathology , Riphah College of Veterinary Sciences , Lahore , Pakistan

4. The Vets Animal Hospital , 10-B Near Main Market, Gulberg 2, Lahore , Pakistan

5. Institute of Continuing Education and Extension , Cholistan University of Veterinary and Animal Sciences , Bahawalpur , Pakistan .

Abstract

Abstract The analgesic efficacy of the gabapentin-tramadol combination was compared with meloxicam-tramadol and tramadol perioperative analgesic regimens in cats brought to the clinic for ovariohysterectomy. Thirty adult cats belonging to comparable demographics (age, body weight), were enrolled into a randomized, blinded study after due consent from their owners into four treatment groups. A Gabapentin-Tramadol group (GT-group, n = 10), Meloxicam-Tramadol group (MT-group, n = 10), and a Tramadol group (T-group, n = 10) were formed. Gabapentin capsules at 50 mg were administered orally 2 hours before surgery while the rest received a placebo dose. Tramadol (2 mg/kg, IM) and meloxicam at (0.2 mg/kg, SC) were injected immediately prior to anesthetic premedication. Anesthetic protocol involved premedication with ketamine and xylazine, while anesthesia was induced using propofol. Inhalant isoflurane anesthesia was used to maintain a surgical plane. GT group scored lower on IVAS as well as CPS than MT group, and T group for up to 8 hours after surgery. The mechanical nociceptive threshold remained higher (98±0) for up to 12 hours postoperatively a nd serum cortisol concentrations remained significantly lower during the 24hr period. The addition of gabapentin to the tramadol regimen significantly improved analgesia and mechanical nociceptive threshold than when used on its own.

Publisher

Walter de Gruyter GmbH

Subject

General Veterinary

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