Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1<i>H</i>)-thiones-Reference-Cited by-同舟云学术

Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1H)-thiones

Published:2024-01-01 Issue:1 Volume:35 Page:36-42
ISSN:2286-038X
Container-title:Ovidius University Annals of Chemistry
language:en
Short-container-title:

Author:

Venkatraman Rajendran¹,Divya Jaganathan¹,Gayathri Pannerselvam¹,Thirunarayanan Ganesamoorthy²,Muthuvel Inbasekaran¹²

Affiliation:

1. Department of Chemistry , Annamalai University , Annamalainagar - , India

2. Department of Chemistry , MR Government Arts College , Mannargudi - , India

Abstract

Abstract The objective of this study was to synthesize some novel substituted 4-(2-methoxynaphthalen-6-yl) pyrimidine- 2(1H)-thione compounds using sodium hydroxide catalyzed three component condensation and cyclization reaction of substituted 6-methoxy-2-acetonapthone, various substituted benzaldehydes and thiourea. These thione derivatives were characterized by their analytical, physical, and spectroscopic data. In addition, the in vitro antibacterial activities of these pyrimidine derivatives were evaluated using Bauer-Kirby disc diffusion method.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/auoc-2024-0005

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