Author:
Holm Niels Bjerre,Pineda Rebeca Sequera,Andersen David Wederkinck,Rasmussen Brian Schou,Dalsgaard Petur Weihe,Hoegberg Lotte C.G.,Johansen Sys Stybe,Linnet Kristian
Abstract
ABSTRACT
A target screening method for the detection of 13 synthetic cannabinoids in whole blood was developed and validated. Samples
underwent automated solid-phase extraction, and sample extracts were analyzed by liquid chromatography-positive electrospray
ionization-tandem mass spectrometry using two transitions in multiple reaction monitoring mode. The limit of detection was between
0.1-2.5 ng/mL for the compounds except HU-210, and extraction recovery ranged from 59 to 78%. The method was used to screen 393
Danish traffic cases from 2012, where the driver was suspected of driving under the influence of drugs. No synthetic cannabinoids were
identified in these samples. Additionally, the method was applied to a clinical intoxication case, and the synthetic cannabinoid AM-
2201 was identified in serum. We conclude that the prevalence of driving under the influence of synthetic cannabinoids in Denmark is
likely to be low, and that synthetic cannabinoids are most likely to be encountered in the clinical setting.
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