The Role of Meningococcal Porin B in Protein-Protein Interactions with Host Cells-Reference-Cited by-同舟云学术

The Role of Meningococcal Porin B in Protein-Protein Interactions with Host Cells

Published:2018-03-01 Issue:1 Volume:62 Page:52-58
ISSN:2453-7837
Container-title:Folia Veterinaria
language:en
Short-container-title:

Author:

Káňová E.¹,Jiménez-Munguía I.¹,Čomor Ľ.¹,Tkáčová Z.¹,Širochmanová I.¹,Bhide K.¹,Bhide M.¹²

Affiliation:

1. Laboratory of Biomedical Microbiology and Immunology , University of Veterinary Medicine and Pharmacy , Kosice

2. Institute of Neuroimmunology, Slovak Academy of Sciences , Bratislava , Slovakia

Abstract

Abstract Neisseria meningitidis is a Gram-negative diplococcus responsible for bacterial meningitis and fatal sepsis. Ligand-receptor interactions are one of the main steps in the development of neuroinvasion. Porin B (PorB), neisserial outer membrane protein (ligand), binds to host receptors and triggers many cell signalling cascades allowing the meningococcus to damage the host cells or induce immune cells responses via the TLR2-dependent mechanisms. In this paper, we present a brief review of the structure and function of PorB.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/fv-2018-0008

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